Hematopoietic Stem Cell Development, Niches, and Signaling Pathways | Zendy

Kamonnaree Chotinantakul | Zendy; Wilairat Leeanansaksiri | Zendy

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Hematopoietic Stem Cell Development, Niches, and Signaling Pathways

Author(s) -

Kamonnaree Chotinantakul,

Wilairat Leeanansaksiri

Publication year - 2012

Publication title -

bone marrow research

Language(s) - English

Resource type - Journals

eISSN - 2090-2999

pISSN - 2090-3006

DOI - 10.1155/2012/270425

Subject(s) - haematopoiesis , stem cell , niche , microbiology and biotechnology , transplantation , medicine , hematopoietic stem cell , immune system , immunology , signal transduction , biology , ecology

Hematopoietic stem cells (HSCs) play a key role in hematopoietic system that functions mainly in homeostasis and immune response. HSCs transplantation has been applied for the treatment of several diseases. However, HSCs persist in the small quantity within the body, mostly in the quiescent state. Understanding the basic knowledge of HSCs is useful for stem cell biology research and therapeutic medicine development. Thus, this paper emphasizes on HSC origin, source, development, the niche, and signaling pathways which support HSC maintenance and balance between self-renewal and proliferation which will be useful for the advancement of HSC expansion and transplantation in the future.

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