Synthesis and Biological Activity of Some 3,4-Dihydro-4-(4-substituted aryl)-6-(naptho[2,1-b]furan-2-yl pyrimidine-2(1H)-one Derivatives | Zendy

Sanjeevan S. Gaikwad | Zendy; Venkat S. Suryawanshi | Zendy; K.S. Lohar | Zendy; Dhanaji V. Jadhav | Zendy; Narayan D. Shinde | Zendy

Open Access

Synthesis and Biological Activity of Some 3,4-Dihydro-4-(4-substituted aryl)-6-(naptho[2,1-b]furan-2-yl pyrimidine-2(1H)-one Derivatives

Author(s) -

Sanjeevan S. Gaikwad,

Venkat S. Suryawanshi,

K.S. Lohar,

Dhanaji V. Jadhav,

Narayan D. Shinde

Publication year - 2011

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2012/258672

Subject(s) - potassium hydroxide , chemistry , pyrimidine , aryl , antifungal , elemental analysis , proton nmr , furan , antibacterial activity , medicinal chemistry , organic chemistry , combinatorial chemistry , stereochemistry , bacteria , alkyl , medicine , dermatology , biology , genetics

A series of new oxopyrimidine were prepared by cyclocondensation route with various substituted chalcones in presence of alcoholic solution of potassium hydroxide at reflux temperature. The synthesized oxopyrimidine derivatives were characterized by means of their IR, 1H NMR, mass spectral data and elemental analysis. The synthesized oxopyrimidines derivatives were evaluated for antibacterial and antifungal activities, some of them were found to possess significant activity

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