Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients | Zendy

Dilara Fatma Akın | Zendy; Kadir Sıpahı | Zendy; Tuğba Kayaalp | Zendy; Yonca Eğin | Zendy; Serpil Taşdelen | Zendy; Emin Kürekçi | Zendy; Üstün Ezer | Zendy; Nejat Akar | Zendy

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Factor V Leiden and Prothrombin 20210A Mutations among Turkish Pediatric Leukemia Patients

Author(s) -

Dilara Fatma Akın,

Kadir Sıpahı,

Tuğba Kayaalp,

Yonca Eğin,

Serpil Taşdelen,

Emin Kürekçi,

Üstün Ezer,

Nejat Akar

Publication year - 2012

Publication title -

leukemia research and treatment

Language(s) - English

Resource type - Journals

eISSN - 2090-3219

pISSN - 2090-3227

DOI - 10.1155/2012/250432

Subject(s) - medicine , turkish , turkish population , mutation , leukemia , factor v leiden , risk factor , population , gastroenterology , pediatrics , genetics , thrombosis , genotype , gene , biology , environmental health , philosophy , linguistics , venous thrombosis

This study was undertaken to determine the prevalence of the Factor V 1691 G-A and PT 20210 G-A mutations in Turkish children with leukemia. We genotyped 135 pediatric leukemia patients with for these mutations. Eleven (8%) of the 135 patients were heterozygous for the FV 1691 G-A mutation. Seven (5,1%) of the patients carried the PT 20210 G-A heterozygous mutation. Of the 135 patients, only three had thrombotic event, none of which had these two mutations, which is common in Turkish population. Our findings revealed a controversial compared to the previous reports, which needs further investigation.

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