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Purpose . To determine whether the presence of cognitive impairment (CI) affects physical recovery of patients with chronic heart failure (CHF) undergoing a cardiac rehabilitation program (CRP).  Methods . We enrolled 80 CHF patients (M/F = 53/27). CI was evaluated by means of the Mini-Mental State Examination (MMSE), exercise tolerance was evaluated by six-minute walking test (6 mwt). All patients underwent a 6-week CRP program at 50–70% of maximal  V   O2 . Patients were divided into two groups according to their MMSE (group 1: 16–23; group 2: 24–30).  Results . MMSE resulted directly related to ejection fraction ( r  = 0.42;  P  = 0.03), and it was inversely related to creatinine ( r  = −0.36;  P  = 0.04). At 6 week group 1 had a lower increase in distance walked at 6 MWT than group 2 ( P  = 0.008). At multivariate logistic regression MMSE 16–23 predicted a reduced exercise recovery in the overall population (OR = 1.84; 95% CI = 1.50–2.18) and in women (OR = 1.42; 95% CI = 1.22–1.75), while it was not predicted in males.  Conclusions . CI is a marker of advanced CHF and is an independent predictor of lower exercise recovery after CRP.

Cognitive Impairment Affects Physical Recovery of Patients with Heart Failure Undergoing Intensive Cardiac Rehabilitation