Etiopathogenesis of Nonalcoholic Steatohepatitis: Role of Obesity, Insulin Resistance and Mechanisms of Hepatotoxicity | Zendy

Praveen Guturu | Zendy; Andrea Duchini | Zendy

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Etiopathogenesis of Nonalcoholic Steatohepatitis: Role of Obesity, Insulin Resistance and Mechanisms of Hepatotoxicity

Author(s) -

Praveen Guturu,

Andrea Duchini

Publication year - 2012

Publication title -

international journal of hepatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.734

H-Index - 14

eISSN - 2090-3448

pISSN - 2090-3456

DOI - 10.1155/2012/212865

Subject(s) - medicine , pathogenesis , nonalcoholic fatty liver disease , insulin resistance , etiology , cirrhosis , incidence (geometry) , obesity , disease , nonalcoholic steatohepatitis , fatty liver , chronic liver disease , diabetes mellitus , steatohepatitis , hepatocellular carcinoma , gastroenterology , liver disease , bioinformatics , endocrinology , biology , physics , optics

Incidence of nonalcoholic fatty liver disease is increasing with an estimated prevalence of 20–30% in developed nations. This is leading to increased incidence of chronic liver disease, cirrhosis, and hepatocellular cancer. It is critical to understand the etiology and pathogenesis of any disease to create therapeutic targets and develop new treatments. In this paper we discuss the etiology and pathogenesis of nonalcoholic steatohepatitis with special focus on obesity, role of insulin resistance, and molecular mechanisms of hepatotoxicity.

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