Hypertriglyceridemia, Metabolic Syndrome, and Cardiovascular Disease in HIV-Infected Patients: Effects of Antiretroviral Therapy and Adipose Tissue Distribution | Zendy

J.P.H. van Wijk | Zendy; Manuel Castro Cabezas | Zendy

Open Access

Hypertriglyceridemia, Metabolic Syndrome, and Cardiovascular Disease in HIV-Infected Patients: Effects of Antiretroviral Therapy and Adipose Tissue Distribution

Author(s) -

J.P.H. van Wijk,

Manuel Castro Cabezas

Publication year - 2011

Publication title -

international journal of vascular medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.411

H-Index - 27

eISSN - 2090-2832

pISSN - 2090-2824

DOI - 10.1155/2012/201027

Subject(s) - medicine , hypertriglyceridemia , lipodystrophy , cart , insulin resistance , hyperlipidemia , disease , population , metabolic syndrome , diabetes mellitus , postprandial , antiretroviral therapy , human immunodeficiency virus (hiv) , obesity , insulin , immunology , cholesterol , endocrinology , viral load , triglyceride , environmental health , mechanical engineering , engineering

The use of combination antiretroviral therapy (CART) in HIV-infected patients has resulted in a dramatic decline in AIDS-related mortality. However, mortality due to non-AIDS conditions, particularly cardiovascular disease (CVD) seems to increase in this population. CART has been associated with several metabolic risk factors, including insulin resistance, low HDL-cholesterol, hypertriglyceridemia and postprandial hyperlipidemia. In addition, HIV itself, as well as specific antiretroviral agents, may further increase cardiovascular risk by interfering with endothelial function. As the HIV population is aging, CVD may become an increasingly growing health problem in the future. Therefore, early diagnosis and treatment of cardiovascular risk factors is warranted in this population. This paper reviews the contribution of both, HIV infection and CART, to insulin resistance, postprandial hyperlipidemia and cardiovascular risk in HIV-infected patients. Strategies to reduce cardiovascular risk are also discussed.

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