A Solvent-Free Protocol for the Green Synthesis of 5-Arylidene-2,4-thiazolidinediones Using Ethylenediamine Diacetate as Catalyst | Zendy

Yuliang Zhang | Zendy; Zhongqiang Zhou | Zendy

Open Access

A Solvent-Free Protocol for the Green Synthesis of 5-Arylidene-2,4-thiazolidinediones Using Ethylenediamine Diacetate as Catalyst

Author(s) -

Yuliang Zhang,

Zhongqiang Zhou

Publication year - 2012

Publication title -

organic chemistry international

Language(s) - English

Resource type - Journals

eISSN - 2090-2018

pISSN - 2090-200X

DOI - 10.1155/2012/194784

Subject(s) - knoevenagel condensation , catalysis , chemistry , ethylenediamine , solvent , organic chemistry , reaction conditions , condensation , combinatorial chemistry , physics , thermodynamics

A simple and efficient synthesis of 5-arylidene-2,4-thiazolidinediones by the Knoevenagel condensation of aromatic aldehydes with 2,4-thiazolidinedione catalyzed by ethylenediamine diacetate under solvent-free conditions is described. The major advantages of this method are simple experimental and work-up procedures, solvent-free reaction conditions, small amount of catalyst, short reaction time, high yields, and utilization of an inexpensive and reusable catalyst

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