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Purpose . Genetic polymorphisms of  MICA  and  DEPDC5  have been reported to correlate with progression to hepatocellular carcinoma (HCC) in chronic hepatitis C patients. However, correlation of these genetic variants with HCC recurrence following hepatectomy has not yet been clarified.  Methods . Ninety-six consecutive HCC patients who underwent hepatectomy, including 64 patients who were hepatitis C virus (HCV) positive, were genotyped for  MICA  (rs2596542) and  DEPDC5  (rs1012068). Recurrence-free survival rates (RFS) were compared for each genotype.  Results . Five-year HCC recurrence-free survival (RFS) rates following hepatectomy were 20.7% in  MICA  GG allele carriers, 38.7% in GA, and 20.8% in AA, respectively ( P  = 0.72). The five-year RFS rate was 23.8% in  DEPDC5  TT allele carriers and 31.8% in TG/GG, respectively ( P  = 0.47). The survival rates in all (including HCV-negative) patients were also similar among each  MICA  and  DEPDC5  genotype following hepatectomy. Among HCV-positive patients carrying the  DEPDC5  TG/GG allele, low fibrosis stage (F0-2) occurred more often compared with TT carriers ( P  < 0.05).  Conclusions . Neither  MICA  nor  DEPDC5  genetic polymorphism correlates with HCC recurrence following hepatectomy.  DEPDC5  minor genotype data suggest a high susceptibility for HCC development in livers, even those with low fibrosis stages.

Neither MICA Nor DEPDC5 Genetic Polymorphisms Correlate with Hepatocellular Carcinoma Recurrence following Hepatectomy