Eosinophilic Esophagitis in Pediatrics: The Worst of all Possible Allergy Worlds?

Eosinophilic esophagitis (EoE) is a relatively uncommon allergic disease. Presenting with variable gastrointestinal symptoms, the definitive diagnosis is made after esophageal visualization and histological confirmation of excessive esophageal eosinophils. The scientific discovery of the pathophysiology of EoE has been aided by its relationship to other common and well-recognized allergic diseases. Similarities and important differences have emerged to distinguish EoE as a significant pediatric allergic disease with unique medical care requirements.