Xenograft Enriched with Autologous Bone Marrow in Inlay Reconstructions: A Tomographic and Histomorphometric Study in Rabbit Calvaria | Zendy

Marcelo de Oliveira e Silva | Zendy; André Antônio Pelegrine | Zendy; Alexandre Alves Pinheiro da Silva | Zendy; Luiz Roberto Manhães Júnior | Zendy; Rafael S. Oliveira | Zendy; Silvana Gaiba | Zendy; Antônio Carlos Aloise | Zendy; Lydia Masako Ferreira | Zendy

Open Access

Xenograft Enriched with Autologous Bone Marrow in Inlay Reconstructions: A Tomographic and Histomorphometric Study in Rabbit Calvaria

Author(s) -

Marcelo de Oliveira e Silva,

André Antônio Pelegrine,

Alexandre Alves Pinheiro da Silva,

Luiz Roberto Manhães Júnior,

Rafael S. Oliveira,

Silvana Gaiba,

Antônio Carlos Aloise,

Lydia Masako Ferreira

Publication year - 2012

Publication title -

international journal of biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.576

H-Index - 28

eISSN - 1687-8795

pISSN - 1687-8787

DOI - 10.1155/2012/170520

Subject(s) - calvaria , bone marrow , parietal bone , inlay , bone healing , medicine , dentistry , anatomy , pathology , chemistry , skull , in vitro , biochemistry

Objective . The aim of this study was to evaluate the bone healing after the usage of a scaffold enriched with bone marrow. Study Design . Ten rabbits were divided into 2 groups of 5 animals. Bilateral 12 mm diameter defects were created in the parietal bones. In control group Bio-Oss were inserted in both defects and, in experimental group, Bio-Oss enriched with autologous bone marrow were inserted in both defects. In these two groups, one of the calvarial defects was covered with Bio-Gide. The rabbits were sacrified 8 weeks after surgery and both CT and histomorphometric analysis were done. Results . The CT showed a lower remaining defect area in the experimental group covered with Bio-Gide when compared with control group, with and without Bio-Gide. The histomorphometrics showed no difference between groups regarding the non-vital mineralized tissue area. For vital mineralized tissue area, the experimental group covered with Bio-Gide obtained a higher percentage area when compared with control group, with and without Bio-Gide. For non-mineralized tissue area, the experimental group covered with Bio-Gide obtained a lower percentage area when compared with control group, with and without Bio-Gide. Conclusion . Both autologous bone marrow and membrane can contribute to the enhancement of bone healing.

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