Innate Immune Activation and Subversion of Mammalian Functions byLeishmaniaLipophosphoglycan | Zendy

Luis H. Franco | Zendy; Stephen M. Beverley | Zendy; Dario S. Zamboni | Zendy

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Innate Immune Activation and Subversion of Mammalian Functions byLeishmaniaLipophosphoglycan

Author(s) -

Luis H. Franco,

Stephen M. Beverley,

Dario S. Zamboni

Publication year - 2012

Publication title -

journal of parasitology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.46

H-Index - 27

eISSN - 2090-0031

pISSN - 2090-0023

DOI - 10.1155/2012/165126

Subject(s) - lipophosphoglycan , leishmania , subversion , infectivity , innate immune system , biology , parasite hosting , immune system , glycoconjugate , microbiology and biotechnology , immunology , leishmania major , bioinformatics , virus , politics , world wide web , computer science , law , political science

Leishmania promastigotes express several prominent glycoconjugates, either secreted or anchored to the parasite surface. Of these lipophosphoglycan (LPG) is the most abundant, and along with other phosphoglycan-bearing molecules, plays important roles in parasite infectivity and pathogenesis in both the sand fly and the mammalian host. Besides its contribution for parasite survival in the sand fly vector, LPG is important for modulation the host immune responses to favor the establishment of mammalian infection. This review will summarize the current knowledge regarding the role of LPG in Leishmania infectivity, focusing on the interaction of LPG and innate immune cells and in the subversion of mammalian functions by this molecule.

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