A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives | Zendy

Sunakar Panda | Zendy; Jagat Krushna Tripathy | Zendy

Open Access

A Comparative Study of Inclusion Complexes of Orthosubstituted [Arylidenamino]-1,3,4- thiadiazino[6,5b] Indole Derivatives

Author(s) -

Sunakar Panda,

Jagat Krushna Tripathy

Publication year - 2011

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2012/156346

Subject(s) - indole test , enthalpy , chemistry , solubility , stability constants of complexes , inclusion (mineral) , antibacterial activity , entropy (arrow of time) , stereochemistry , computational chemistry , medicinal chemistry , organic chemistry , thermodynamics , aqueous solution , mineralogy , biology , bacteria , physics , genetics

Some[Arylidenamino]-1,3,4-thiadiazino[6,5b] indoles have been synthesized starting from indole-2,3-dione, thiosemicarbazide and aromatic aldehydes with activating and deactivating groups. Inclusion complexes of these compounds have been prepared with β-cyclodextrin so as increase the solubility and bioaccessibility. Thermodynamic properties like change in free energy, change in enthalpy, change in entropy and stability constant of the inclusion complexes have been determined to know whether the inclusion complex formation is thermodynamically allowed or not. The compounds and their inclusion complexes are also screened againt S.aureus and E.coli.to know the antibacterial activity change after inclusion complex formation The antioxidant activities are also studied

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