Reversal of Jaundice in Two Patients with Inoperable Cholangiocarcinoma Treated with Cisplatin and Gemcitabine Combination | Zendy

Maarten Criel | Zendy; F. Geurs | Zendy; S. Ponette | Zendy; Katrien Bulte | Zendy; J. Ponette | Zendy

Open Access

Reversal of Jaundice in Two Patients with Inoperable Cholangiocarcinoma Treated with Cisplatin and Gemcitabine Combination

Author(s) -

Maarten Criel,

F. Geurs,

S. Ponette,

Katrien Bulte,

J. Ponette

Publication year - 2012

Publication title -

case reports in hepatology

Language(s) - English

Resource type - Journals

eISSN - 2090-6587

pISSN - 2090-6595

DOI - 10.1155/2012/138381

Subject(s) - gemcitabine , jaundice , medicine , tolerability , cisplatin , chemotherapy , bilirubin , oncology , obstructive jaundice , liver function , combination chemotherapy , gastroenterology , adverse effect

Two patients are presented with severe jaundice, due to inoperable cholangiocarcinoma. The chemotherapeutic approach in patients with severe jaundice is discussed. Many schedules of chemotherapy were developed in this tumor type with normal serum bilirubin. We report here the first successful use of cisplatin and gemcitabine combination chemotherapy in these patients. Tolerability was good and liver function tests gradually improved.

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