Visceral Kaposi's Sarcoma Related to Human Herpesvirus-8 in Liver Transplant Recipient: Case Report and Literature Review | Zendy

Hafida Benhammane | Zendy; Gilles Mentha | Zendy; É. Tschanz | Zendy; Omar El Mesbahi | Zendy; P.-Y. Dietrich | Zendy

Open Access

Visceral Kaposi's Sarcoma Related to Human Herpesvirus-8 in Liver Transplant Recipient: Case Report and Literature Review

Author(s) -

Hafida Benhammane,

Gilles Mentha,

É. Tschanz,

Omar El Mesbahi,

P.-Y. Dietrich

Publication year - 2012

Publication title -

case reports in oncological medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.173

H-Index - 7

eISSN - 2090-6714

pISSN - 2090-6706

DOI - 10.1155/2012/137291

Subject(s) - medicine , sarcoma , population , human herpesvirus , kaposi's sarcoma , transplantation , surgery , immunology , pathology , environmental health

Background . Kaposi's sarcoma (KS) in transplant recipients is about 400 to 500 times rate in the general population. It is strongly associated to Human herpesvirus-8 (HHV-8) infection which has been found in 95% of KS lesions. The optimal approach to managing posttransplantation KS is to reduce or discontinue immunosuppressive therapy but this strategy carries a risk of the acute rejection of the graft. Recently, the use of an mTOR inhibitor has added new opportunities for KS treatment and prevention. Case Report . We report a case of 24 years-old Turkish woman with visceral HHV-8-associated Kaposi's sarcoma after orthotopic liver transplantation. Conclusion . Posttransplantation KS is considered an experimental model of virus induced tumor suggesting the usefulness of HHV-8 screening in transplant recipient and donor. Therapeutic approaches are complex and require a multidisciplinary team.

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