Binding Studies of a New Water-Soluble Iron(III) Schiff Base Complex to DNA Using Multispectroscopic Methods
Author(s) -
Nahid Shahabadi,
Zeinab Ghasemian,
Saba Hadidi
Publication year - 2012
Publication title -
bioinorganic chemistry and applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.865
H-Index - 35
eISSN - 1565-3633
pISSN - 1687-479X
DOI - 10.1155/2012/126451
Subject(s) - chemistry , schiff base , circular dichroism , dna , minor groove , chloride , absorption (acoustics) , nuclear chemistry , crystallography , inorganic chemistry , stereochemistry , organic chemistry , biochemistry , physics , acoustics
A novel iron(III) complex [Fe(SF)](ClO 4 ) 3 .2H 2 O; in which SF = N,N 0 -bis{5-[(triphenylphosphonium chloride)-methyl] salicylidene}-o-phenylenediamine) has been synthesized and characterized using different physicochemical methods. The binding of this complex with calf thymus (CT) DNA was investigated by circular dichroism, absorption studies, emission spectroscopy, voltammetric studies, and viscosity measurements. The results showed that this complex can bind to DNA via external and groove binding modes.
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