Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet’s Disease | Zendy

Jun Shimizu | Zendy; Tomoko Izumi | Zendy; Noboru Suzuki | Zendy

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Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet’s Disease

Author(s) -

Jun Shimizu,

Tomoko Izumi,

Noboru Suzuki

Publication year - 2012

Publication title -

autoimmune diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.681

H-Index - 32

eISSN - 2090-0422

pISSN - 2090-0430

DOI - 10.1155/2012/105205

Subject(s) - behcet's disease , medicine , pathogenesis , heat shock protein , disease , pathophysiology , shock (circulatory) , c reactive protein , immunology , pathology , inflammation , biology , gene , genetics

Behcet's disease (BD) is a multisystemic inflammatory disease and is characterized by recurrent attacks on eyes, brain, skin, and gut. There is evidence that skewed T-cell responses contributed to its pathophysiology in patients with BD. We found that heat shock proteins (HSPs) reactive T cells were prevalent in patients with BD. Here, we summarize current findings on HSP reactive T cells and their contribution to the pathogenesis in patients with BD.

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