A Polymorphism Within the Connective Tissue Growth Factor (CTGF) Gene has No Effect on Non-Invasive Markers of Beta-Cell Area and Risk of Type 2 Diabetes | Zendy

Olga PivovarovaRamich | Zendy; Eva Fisher | Zendy; Katarzyna Dudziak | Zendy; Iryna Ilkavets | Zendy; Steven Dooley | Zendy; P. A. Slominsky | Zendy; Limborskaia Sa | Zendy; Martin O. Weickert | Zendy; Joachim Spranger | Zendy; Andreas Fritsche | Zendy; Heiner Boeing | Zendy; A. Pfeiffer | Zendy; Natalia Rudovich | Zendy

Open Access

A Polymorphism Within the Connective Tissue Growth Factor (CTGF) Gene has No Effect on Non-Invasive Markers of Beta-Cell Area and Risk of Type 2 Diabetes

Author(s) -

Olga PivovarovaRamich,

Eva Fisher,

Katarzyna Dudziak,

Iryna Ilkavets,

Steven Dooley,

P. A. Slominsky,

Limborskaia Sa,

Martin O. Weickert,

Joachim Spranger,

Andreas Fritsche,

Heiner Boeing,

A. Pfeiffer,

Natalia Rudovich

Publication year - 2011

Publication title -

disease markers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.912

H-Index - 66

eISSN - 1875-8630

pISSN - 0278-0240

DOI - 10.1155/2011/971702

Subject(s) - ctgf , type 2 diabetes , medicine , biology , endocrinology , allele , connective tissue , diabetes mellitus , genetics , growth factor , gene , receptor

Chromosomal locus 6q23 is strongly linked to type 2 diabetes (T2DM) and related features including insulin secretion in various ethnic populations. Connective tissue growth factor (CTGF) gene is an interesting T2DM candidate gene in this chromosome region. CTGF is a key mediator of progressive pancreatic fibrosis up-regulated in type 2 diabetes. In contrast, CTGF inactivation in mice compromises islet cell proliferation during embryogenesis. The aim of our study was to investigate an impact of CTGF genetic variation on pancreatic beta-cell function and T2DM pathogenesis. We studied the effect of a common CTGF polymorphism rs9493150 on the risk of the T2DM development in three independent German cohorts. Specifically, the association between CTGF polymorphism and non-invasive markers of beta-cell area derived from oral glucose tolerance test was studied in subjects without diabetes. Neither in the Metabolic Syndrome Berlin Potsdam (MESYBEPO) study ( n = 1026) (OR = 0.637, CI (0.387–1.050); p = 0.077) nor in the European Prospective Investigation into Cancer and Nutrition-Potsdam (EPIC-Potsdam) ( n = 3049) cohort (RR = 0.77 CI (0.49–1.20), p = 0.249 for the recessive homozygote in general model), a significant association with increased diabetes risk was observed. The risk allele of rs9493150 had also no effect on markers of beta-cell area in the combined analysis of the MESYBEPO and Tübingen Family Study ( n = 1826). In conclusion, the polymorphism rs9493150 in the 5’-untranslated region of the CTGF gene has no association with T2DM risk and surrogate markers of beta-cell area.

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