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ABO Incompatible Kidney Transplantation—Current Status and Uncertainties
Author(s) -
Milljae Shin,
Sung-Joo Kim
Publication year - 2011
Publication title -
journal of transplantation
Language(s) - English
Resource type - Journals
eISSN - 2090-0015
pISSN - 2090-0007
DOI - 10.1155/2011/970421
Subject(s) - abo blood group system , contraindication , medicine , kidney transplantation , desensitization (medicine) , transplantation , immunology , intensive care medicine , pathology , alternative medicine , receptor
In the past, ABO blood group incompatibility was considered an absolute contraindication for kidney transplantation. Progress in defined desensitization practice and immunologic understanding has allowed increasingly successful ABO incompatible transplantation during recent years. This paper focused on the history, disserted outcomes, desensitization modalities and protocols, posttransplant immunologic surveillance, and antibody-mediated rejection in transplantation with an ABO incompatible kidney allograft. The mechanism underlying accommodation and antibody-mediated injury was also described.

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