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This study evaluated the wound healing activity of hydroalcoholic leaf extract of  Oncidium flexuosum  Sims. (Orchidaceae), an important native plant of Brazil, combined or not with microcurrent stimulation.  Wistar  rats were randomly divided into four groups of nine animals: control (C), topical application of the extract (OF), treated with a microcurrent (10  μ A/2 min) (MC), and topical application of the extract plus microcurrent (OF + MC). Tissue samples were obtained 2, 6, and 10 days after injury and submitted to structural and morphometric analysis. The simultaneous application of OF + MC was found to be highly effective in terms of the parameters analyzed ( P  < .05), with positive effects on the area of newly formed tissue, number of fibroblasts, number of newly formed blood vessels, and epithelial thickness. Morphometric data confirmed the structural findings. The  O. flexuosum  leaf extract contains active compounds that speed the healing process, especially when applied simultaneously with microcurrent stimulation.

evidence-based complementary and alternative medicine

Effects of the Topical Application of Hydroalcoholic Leaf Extract of<i>Oncidium flexuosum</i>Sims. (Orchidaceae) and Microcurrent on the Healing of Wounds Surgically Induced in<i>Wistar</i>Rats

Effects of the Topical Application of Hydroalcoholic Leaf Extract ofOncidium flexuosumSims. (Orchidaceae) and Microcurrent on the Healing of Wounds Surgically Induced inWistarRats