Effects of the Topical Application of Hydroalcoholic Leaf Extract ofOncidium flexuosumSims. (Orchidaceae) and Microcurrent on the Healing of Wounds Surgically Induced inWistarRats | Zendy

Fernanda Oliveira de Gaspari de Gaspi | Zendy; Mary Ann Foglio | Zendy; João Ernesto de Carvalho | Zendy; Gláucia Maria Tech dos Santos | Zendy; Milene Testa | Zendy; José Roberto Passarini | Zendy; Cristiano Pedroso de Moraes | Zendy; Marcelo Augusto Marretto Esquisatto | Zendy; Josué Sampaio Mendonça | Zendy; Fernanda Aparecida Sampaio Mendonça | Zendy

Open Access

Effects of the Topical Application of Hydroalcoholic Leaf Extract ofOncidium flexuosumSims. (Orchidaceae) and Microcurrent on the Healing of Wounds Surgically Induced inWistarRats

Author(s) -

Fernanda Oliveira de Gaspari de Gaspi,

Mary Ann Foglio,

João Ernesto de Carvalho,

Gláucia Maria Tech dos Santos,

Milene Testa,

José Roberto Passarini,

Cristiano Pedroso de Moraes,

Marcelo Augusto Marretto Esquisatto,

Josué Sampaio Mendonça,

Fernanda Aparecida Sampaio Mendonça

Publication year - 2011

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2011/950347

Subject(s) - orchidaceae , stimulation , wound healing , chemistry , biology , medicine , botany , surgery , neuroscience

This study evaluated the wound healing activity of hydroalcoholic leaf extract of Oncidium flexuosum Sims. (Orchidaceae), an important native plant of Brazil, combined or not with microcurrent stimulation. Wistar rats were randomly divided into four groups of nine animals: control (C), topical application of the extract (OF), treated with a microcurrent (10 μ A/2 min) (MC), and topical application of the extract plus microcurrent (OF + MC). Tissue samples were obtained 2, 6, and 10 days after injury and submitted to structural and morphometric analysis. The simultaneous application of OF + MC was found to be highly effective in terms of the parameters analyzed ( P < .05), with positive effects on the area of newly formed tissue, number of fibroblasts, number of newly formed blood vessels, and epithelial thickness. Morphometric data confirmed the structural findings. The O. flexuosum leaf extract contains active compounds that speed the healing process, especially when applied simultaneously with microcurrent stimulation.

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