Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples | Zendy

Oya Cingöz | Zendy; John M. Coffin | Zendy

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Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples

Author(s) -

Oya Cingöz,

John M. Coffin

Publication year - 2011

Publication title -

advances in virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.956

H-Index - 25

eISSN - 1687-8647

pISSN - 1687-8639

DOI - 10.1155/2011/940210

Subject(s) - gammaretrovirus , virology , murine leukemia virus , endogenous retrovirus , leukemia , biology , virus , genome , endogeny , dna , genetics , gene , endocrinology

Xenotropic-murine-leukemia-virus-related virus (XMRV) was the first gammaretrovirus to be reported in humans. The sequence similarity between XMRV and murine leukemia viruses (MLVs) was consistent with an origin of XMRV from one or more MLVs present as endogenous proviruses in mouse genomes. Here, we review the relationship of the human and mouse virus isolates and discuss the potential complications associated with the detection of MLV-like sequences from clinical samples.

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