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Background . We encountered repeatedly, in our clinical practice, discordant results between UBT and histopathology about  H. pylori  infection.  Goal . To study the diagnostic accuracy of Heliprobe  14 C-urea breath test ( 14 C-UBT) for detection of  H. pylori  infection in an Iranian population.  Study . We enrolled 125 dyspeptic patients in our study. All of them underwent gastroscopy, and four gastric biopsies (three from the antrum and one from the corpus) were obtained. One of the antral biopsies was utilized for a rapid urease test (RUT), and three others were evaluated under microscopic examination. Sera from all patients were investigated for the presence of  H. pylori  IgG antibodies. The  14 C-UBT was performed on all subjects using Heliprobe kit, and results were analyzed against the following gold standard (GS):  H. pylori  infection considered positive when any two of three diagnostic methods (histopathology, RUT, serology) are positive.  Results . According to data analysis, the Heliprobe  14 C-UBT had 94% sensitivity, 100% specificity, 93% negative predictive value (NPV), 100% positive predictive value (PPV), and 97% accuracy, compared with GS.  Conclusion . The Heliprobe  14 C-UBT is an easy-to-perform, rapid-response, and accurate test for  H. pylori  diagnosis, suitable for office use.

Clinical Validation of an Office-Based14C-UBT (Heliprobe) forH. pyloriDiagnosis in Iranian Dyspeptic Patients

Clinical Validation of an Office-Based¹⁴C-UBT (Heliprobe) forH. pyloriDiagnosis in Iranian Dyspeptic Patients