Comparative Evaluation of the Reticulocyte Hemoglobin Content Assay When Screening for Iron Deficiency in Elderly Anemic Patients | Zendy

Torbjörn Karlsson | Zendy

Open Access

Comparative Evaluation of the Reticulocyte Hemoglobin Content Assay When Screening for Iron Deficiency in Elderly Anemic Patients

Author(s) -

Torbjörn Karlsson

Publication year - 2011

Publication title -

anemia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.921

H-Index - 25

eISSN - 2090-1275

pISSN - 2090-1267

DOI - 10.1155/2011/925907

Subject(s) - medicine , soluble transferrin receptor , hemoglobin , transferrin saturation , ferritin , gold standard (test) , iron deficiency , anemia , mean corpuscular hemoglobin , reticulocyte , mean corpuscular volume , mean corpuscular hemoglobin concentration , gastroenterology , iron deficiency anemia , transferrin , endocrinology , iron status , biochemistry , biology , messenger rna , gene

The aim of this study was to evaluate sensitivity and specificity for reticulocyte hemoglobin content (CHr) compared to other hematimetric and biochemical iron parameters, in particular, mean corpuscular hemoglobin (MCH), when screening for iron deficiency in elderly anemic patients. Bone marrow staining negative for iron was used as the gold standard criterion for iron deficiency anemia (IDA). Sensitivity and specificity for CHr, soluble transferrin receptor (sTfR), soluble transferrin receptor/log ferritin (TfR-F index), ferritin, MCH, and transferrin saturation were determined. The best cut-off point for CHr was 30.5 pg corresponding to a sensitivity and specificity of 93% and 69% for IDA, respectively. For MCH, a sensitivity of 93% and a specificity of 86%, respectively, correspond to an optimal cut-off of 28.5 pg. Analysis of CHr was not superior to MCH with respect to sensitivity and specificity when screening for IDA in elderly anemic patients.

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