Open AccessOne-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG
Author(s) -
B. Siva Kumar,
Y. Haranadha Reddy,
Radha Rani Chinthaparthi,
G. Chnadra Sekhar Reddy
Publication year - 2011
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2090-9063
pISSN - 2090-9071
DOI - 10.1155/2011/906320
Subject(s) - toluene , antimicrobial , chemistry , catalysis , reaction conditions , one pot synthesis , organic chemistry
α -Aminophosphonates (4a-j) were synthesized in one-pot simultaneous reaction of 4-bromo-3-methyl benzenamine ( 1 ), dimethylphosphite ( 3 ) and different aromatic aldehydes (2a-j) by Kabachnik-Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux temperature afforded 4a-j in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity.
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