Open AccessMaturation of the GABAergic Transmission in Normal and Pathologic Motoneurons
Author(s) -
AnneEmilie Allain,
Hervé Le Corronc,
Alain Delpy,
William Cazenave,
Pierre Meyrand,
Pascal Legendre,
Pascal Branchereau
Publication year - 2011
Publication title -
neural plasticity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.288
H-Index - 68
eISSN - 2090-5904
pISSN - 1687-5443
DOI - 10.1155/2011/905624
Subject(s) - gabaergic , inhibitory postsynaptic potential , neuroscience , ionotropic effect , brainstem , gabaa receptor , excitatory postsynaptic potential , gamma aminobutyric acid , biology , neurotransmitter , neurotransmission , glutamate receptor , chemistry , central nervous system , receptor , biochemistry
γ -aminobutyric acid (GABA) acting on Cl − -permeable ionotropic type A (GABA A ) receptors (GABA A R) is the major inhibitory neurotransmitter in the adult central nervous system of vertebrates. In immature brain structures, GABA exerts depolarizing effects mostly contributing to the expression of spontaneous activities that are instructive for the construction of neural networks but GABA also acts as a potent trophic factor. In the present paper, we concentrate on brainstem and spinal motoneurons that are largely targeted by GABAergic interneurons, and we bring together data on the switch from excitatory to inhibitory effects of GABA, on the maturation of the GABAergic system and GABA A R subunits. We finally discuss the role of GABA and its GABA A R in immature hypoglossal motoneurons of the spastic (SPA) mouse, a model of human hyperekplexic syndrome.
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