The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats | Zendy

Yang Gao | Zendy; Xinguo Deng | Zendy; Na Li | Zendy; Guangwei Luo | Zendy; Peter Chung | Zendy

Open Access

The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats

Author(s) -

Yang Gao,

Xinguo Deng,

Na Li,

Guangwei Luo,

Peter Chung

Publication year - 2011

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2011/903261

Subject(s) - spore , fish oil , fish <actinopterygii> , lesion , nitrosourea , ganoderma , chemistry , biology , food science , pathology , botany , fishery , ganoderma lucidum , medicine , genetics , chemotherapy

Purpose . To compare Ganoderma spores lipid (GSL) and fish oil (FO) in inhibiting retinal photoreceptor cell lesions induced by N-methyl-N-nitrosourea (MNU) in rats. Methods . 120 rats were untreated (normal control, NC group) or treated with a single intraperitoneal injection of 40 mg/kg MNU (MNU group) then treated with GSL (GSL group) or FO (FO group). Eyes were obtained at 1, 3, 5, 7, and 10 days. Results . Light microscopy assay demonstrated that GSL and FO alleviated rat retinal photoreceptor cell damage (GSL and FO versus MNU group P < .001) similarly (GSL versus FO group P = .980). Electron microscopy confirmed that GSL and FO reversed damage to photoreceptor segments and photoreceptor cell nuclei. GSL-treated rats showed significantly elevated a-wave and b-wave amplitudes over MNU group ( P < .05) but less than NC group ( P < .05) and not significantly different from FO group ( P > .05). Conclusion . GSL, like FO, alleviates rat retinal photoreceptor cell damage induced by MNU.

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