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Purpose . To compare Ganoderma spores lipid (GSL) and fish oil (FO) in inhibiting retinal photoreceptor cell lesions induced by N-methyl-N-nitrosourea (MNU) in rats.   Methods . 120 rats were untreated (normal control, NC group) or treated with a single intraperitoneal injection of 40 mg/kg MNU (MNU group) then treated with GSL (GSL group) or FO (FO group). Eyes were obtained at 1, 3, 5, 7, and 10 days.   Results . Light microscopy assay demonstrated that GSL and FO alleviated rat retinal photoreceptor cell damage (GSL and FO versus MNU group  P  < .001) similarly (GSL versus FO group  P  = .980). Electron microscopy confirmed that GSL and FO reversed damage to photoreceptor segments and photoreceptor cell nuclei. GSL-treated rats showed significantly elevated a-wave and b-wave amplitudes over MNU group ( P  < .05) but less than NC group ( P  < .05) and not significantly different from FO group ( P  > .05).  Conclusion . GSL, like FO, alleviates rat retinal photoreceptor cell damage induced by MNU.

The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats