Metal-Based Biologically Active Compounds: Synthesis, Spectral, and Antimicrobial Studies of Cobalt, Nickel, Copper, and Zinc Complexes of Triazole-Derived Schiff Bases | Zendy

Kiran Singh | Zendy; Yogender Kumar | Zendy; Parvesh Puri | Zendy; Chetan Sharma | Zendy; K. R. Aneja | Zendy

Open Access

Metal-Based Biologically Active Compounds: Synthesis, Spectral, and Antimicrobial Studies of Cobalt, Nickel, Copper, and Zinc Complexes of Triazole-Derived Schiff Bases

Author(s) -

Kiran Singh,

Yogender Kumar,

Parvesh Puri,

Chetan Sharma,

K. R. Aneja

Publication year - 2011

Publication title -

bioinorganic chemistry and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.865

H-Index - 35

eISSN - 1565-3633

pISSN - 1687-479X

DOI - 10.1155/2011/901716

Subject(s) - chemistry , schiff base , aspergillus niger , cobalt , copper , zinc , nickel , thermogravimetric analysis , metal , triazole , denticity , octahedral molecular geometry , polymer chemistry , antibacterial activity , inorganic chemistry , nuclear chemistry , organic chemistry , bacteria , biochemistry , biology , genetics

A series of cobalt, nickel, copper, and zinc complexes of bidentate Schiff bases derived from the condensation reaction of 4-amino-5-mercapto-3-methyl/ethyl-1,2,4-triazole with 2,4-dichlorobenzaldehyde were synthesized and tested as antimicrobial agents. The synthesized Schiff bases and their metal complexes were characterized with the aid of elemental analyses, magnetic moment measurements, spectroscopic and thermogravimetric techniques. The presence of coordinated water in metal complexes was supported by infrared and thermal gravimetric studies. A square planar geometry was suggested for Cu(II) and octahedral geometry proposed for Co(II), Ni(II), and Zn(II) complexes. The Schiff bases and their metal complexes have been screened for antibacterial ( Pseudomonas aeruginosa, Bacillus subtilis ) and antifungal activities ( Aspergillus niger, A. flavus ). The metal complexes exhibited significantly enhanced antibacterial and antifungal activity as compared to their simple Schiff bases.

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