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Current efforts have proven inadequate to stop the transmission of  Plasmodium  parasites, and hence the spread of malaria, by  Anopheles  mosquitoes. Therefore, a novel arsenal of strategies for inhibiting  Plasmodium  infection of mosquitoes is urgently needed. In this paper, we summarize research on two approaches to malaria control, a low-tech strategy based on parasite inhibition by the mosquito's natural microflora, and a high-tech strategy using genetic modification of mosquitoes that renders them resistant to infection and discuss advantages and disadvantages for both approaches.

Low- and High-Tech Approaches to ControlPlasmodiumParasite Transmission byAnophelesMosquitoes