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Objective . To better understand attributes of ART-associated HIV-induced T-cell responses that might be therapeutically harnessed.   Methods . CD8 +  T-cell responses were evaluated in some HIV-1 chronically infected participants of the fixed duration STI substudy of the DART trial. Magnitudes, breadths, and functionality of IFN- γ  and Perforin responses were compared in STI ( n  = 42) and continuous treatment (CT) ( n  = 46) before and after a single STI cycle when the DART STI trial was stopped early due to inferior clinical outcome in STI participants.   Results . STI and CT had comparable magnitudes and breadths of monofunctional CD8 + IFN γ   +  and CD8 + Perforin +  responses. However, STI was associated with significant decline in breadth of bi-functional (CD8 + IFN γ   + Perforin + ) responses;  P  = .02, Mann-Whitney test.   Conclusions . STI in individuals initiated onto ART at <200 CD4 +  T-cell counts/ μ l significantly reduced occurrence of bifunctional CD8 + IFN γ   + /Perforin +  responses. These data add to others that found no evidence to support STI as a strategy to improve HIV-specific immunity during ART.

aids research and treatment

CD8<sup>+</sup>T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4<sup>+</sup>T Cells &lt;200 Cell/μL: The DART Trial STI Substudy

CD8+T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+T Cells <200 Cell/μL: The DART Trial STI Substudy

CD8⁺T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4⁺T Cells <200 Cell/μL: The DART Trial STI Substudy