Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity | Zendy

Kartick Samanta | Zendy; Mohammad Asif | Zendy; Pooja Pooja | Zendy; Vikas Garg | Zendy; Priyanka Sharma | Zendy; Ravinder Singh | Zendy

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Synthesis of Different Substituted Pyridazinone Derivatives and Their Anticonvulsant Activity

Author(s) -

Kartick Samanta,

Mohammad Asif,

Pooja Pooja,

Vikas Garg,

Priyanka Sharma,

Ravinder Singh

Publication year - 2010

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2011/873470

Subject(s) - anticonvulsant , chemistry , hydrazine (antidepressant) , hydrate , medicinal chemistry , organic chemistry , epilepsy , biochemistry , medicine , psychiatry

6-Phenyl(3᾽-imino-benzylidene)-2,3,4,5-tetrahydro pyridazin-3-one derivatives were synthesized from 6-(3᾽-aminophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with different aldehydes. The respective pyridazinone was prepared by cyclization of appropriate β-(aminophenyl) propionic acid with hydrazine hydrate. The pyridazinone derivatives were tested for anticonvulsant activity by MES (maximal electro shock) method and found that few of them have shown significant anticonvulsant activity.

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