Multiphoton Microscopy for Ophthalmic Imaging | Zendy

Emily A. Gibson | Zendy; Omid Masihzadeh | Zendy; Tim C. Lei | Zendy; David A. Ammar | Zendy; Malik Y. Kahook | Zendy

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Multiphoton Microscopy for Ophthalmic Imaging

Author(s) -

Emily A. Gibson,

Omid Masihzadeh,

Tim C. Lei,

David A. Ammar,

Malik Y. Kahook

Publication year - 2011

Publication title -

journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.818

H-Index - 40

eISSN - 2090-0058

pISSN - 2090-004X

DOI - 10.1155/2011/870879

Subject(s) - optical coherence tomography , medicine , autofluorescence , microscopy , fluorescence lifetime imaging microscopy , confocal microscopy , optics , second harmonic imaging microscopy , second harmonic generation , biomedical engineering , two photon excitation microscopy , raman scattering , raman spectroscopy , fluorescence , pathology , ophthalmology , physics , laser

We review multiphoton microscopy (MPM) including two-photon autofluorescence (2PAF), second harmonic generation (SHG), third harmonic generation (THG), fluorescence lifetime (FLIM), and coherent anti-Stokes Raman Scattering (CARS) with relevance to clinical applications in ophthalmology. The different imaging modalities are discussed highlighting the particular strength that each has for functional tissue imaging. MPM is compared with current clinical ophthalmological imaging techniques such as reflectance confocal microscopy, optical coherence tomography, and fluorescence imaging. In addition, we discuss the future prospects for MPM in disease detection and clinical monitoring of disease progression, understanding fundamental disease mechanisms, and real-time monitoring of drug delivery.

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