Mycobacterial Brain Tuberculomas due to Bacille Calmette‐Guérin Intravesical Chemotherapy for Bladder Cancer: A Case Report and Literature Review | Zendy

Vitaly Golub | Zendy; Prashant Malhotra | Zendy; Shital M. Patel | Zendy

Open Access

Mycobacterial Brain Tuberculomas due to Bacille Calmette‐Guérin Intravesical Chemotherapy for Bladder Cancer: A Case Report and Literature Review

Author(s) -

Vitaly Golub,

Prashant Malhotra,

Shital M. Patel

Publication year - 2011

Publication title -

canadian journal of infectious diseases and medical microbiology

Language(s) - English

Resource type - Journals

eISSN - 1918-1493

pISSN - 1712-9532

DOI - 10.1155/2011/869286

Subject(s) - ethambutol , medicine , tuberculoma , moxifloxacin , immunotherapy , bladder cancer , chemotherapy , complication , cancer , tuberculosis , antibiotics , isoniazid , pathology , microbiology and biotechnology , biology

Bacille Calmette-Guérin (BCG) immunotherapy is widely used for the treatment of superficial bladder cancer. The authors believe that the present report is one of the first to document cerebral BCG tuberculoma in a 73-year-old immunocompetent man, three years after intra-vesical BCG immunotherapy. His workup revealed no identifiable extracranial source. He responded well to treatment with rifampin, ethambutol and moxifloxacin.Patients undergoing intravesical BCG therapy should be closely monitored for the development of this complication. Prolonged antitubercular therapy, possibly including moxifloxacin, appears to be beneficial in the treatment of central nervous system tuberculous infections.

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