Preparation and Characterization of Self-Emulsified Docetaxel | Zendy

Gyeong Hae Kim | Zendy; Ju Young Lee | Zendy; Yun Mi Kang | Zendy; Kkot Nim Kang | Zendy; E. Sle Kim | Zendy; Da Yeon Kim | Zendy; Jae Ho Kim | Zendy; Moon Suk Kim | Zendy

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Preparation and Characterization of Self-Emulsified Docetaxel

Author(s) -

Gyeong Hae Kim,

Ju Young Lee,

Yun Mi Kang,

Kkot Nim Kang,

E. Sle Kim,

Da Yeon Kim,

Jae Ho Kim,

Moon Suk Kim

Publication year - 2010

Publication title -

journal of nanomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.463

H-Index - 66

eISSN - 1687-4129

pISSN - 1687-4110

DOI - 10.1155/2011/860376

Subject(s) - docetaxel , zeta potential , materials science , nuclear chemistry , chromatography , chemical engineering , nanotechnology , chemistry , nanoparticle , medicine , cancer , engineering

The aim of this paper was to prepare a self-microemulsifying docetaxel (Dtx) using PLGA, Tetraglycol, Labrasol, and Cremophor ELP. The prepared Dtx-loaded self-microemulsifying system (SMES) showed the initial size of the range of 80–100 nm with narrow size distribution and the negative zeta-potential values. Its morphology was a spherical shape by atomic force microscopy. In experiment of stability, Dtx-loaded SMES prepared in DW and BSA condition showed good stability at 37∘C for 7 days. The viability of the B16F10 cells incubated with Dtx-loaded SMES, Dtx-solution, and Taxol were decreased as a function of incubation time. In conclusion, we confirmed that Dtx-loaded SMES showed an inhibitory effect for proliferation of B16F10 melanoma cells

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