Magnetically Directed Targeting Aggregation of Radiolabelled Ferrite Nanoparticles | Zendy

YuhFeng Wang | Zendy; ChaoMing Fu | Zendy; MeiHua Chuang | Zendy; ThauMing Cham | Zendy; MeiIng Chung | Zendy

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Magnetically Directed Targeting Aggregation of Radiolabelled Ferrite Nanoparticles

Author(s) -

YuhFeng Wang,

ChaoMing Fu,

MeiHua Chuang,

ThauMing Cham,

MeiIng Chung

Publication year - 2011

Publication title -

journal of nanomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.463

H-Index - 66

eISSN - 1687-4129

pISSN - 1687-4110

DOI - 10.1155/2011/851520

Subject(s) - biodistribution , materials science , nanoparticle , magnetic nanoparticles , ferrite (magnet) , magnetism , iron oxide nanoparticles , nanotechnology , nuclear magnetic resonance , chemical engineering , chemistry , composite material , biochemistry , physics , quantum mechanics , in vitro , engineering

Ferrite magnetic nanoparticles (Fe3O4 or iron (II,III) oxide; 15–25 nm of diameter) were developed. These magnetic nanoparticles are a potential vehicle for magnetically induced target aggregation in living animals. In this preliminary study, the radiochemical purity for the radiolabeled magnetic nanoparticles was examined, and the possibility of the magnetically induced targeting of the radio-nanoparticles was evaluated. Our results showed that radiolabeled ferrite nanoparticles can be used as magnetic targeting agents with high labeling efficiency and stability. These particles can be distributed within living animals via intravenous injection, and the biodistribution of the particles can be potentially controlled by external magnetism. These evaluations will be the groundwork for the future development of delivery techniques for radiopharmaceuticals through external magnetic control

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