Immunolymphoscintigraphy for Metastatic Sentinel Nodes: Test of a Model | Zendy

Annette H. Chakera | Zendy; Boye Schnack Nielsen | Zendy; Jacob Madsen | Zendy; John Rømer | Zendy; Paul E.G. Kristjansen | Zendy; Inge Buch | Zendy; Tina Binderup | Zendy; Christian Ingvar | Zendy; Amarnadh Nalla | Zendy; Andreas Kjær | Zendy; Birger Hesse | Zendy

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Immunolymphoscintigraphy for Metastatic Sentinel Nodes: Test of a Model

Author(s) -

Annette H. Chakera,

Boye Schnack Nielsen,

Jacob Madsen,

John Rømer,

Paul E.G. Kristjansen,

Inge Buch,

Tina Binderup,

Christian Ingvar,

Amarnadh Nalla,

Andreas Kjær,

Birger Hesse

Publication year - 2011

Publication title -

international journal of molecular imaging

Language(s) - English

Resource type - Journals

eISSN - 2090-1712

pISSN - 2090-1720

DOI - 10.1155/2011/828151

Subject(s) - medicine , breast cancer , monoclonal antibody , lymph , sentinel node , antibody , subcutaneous injection , human breast , cancer , cancer research , pathology , immunology

Aim . To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods . We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion . Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.

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