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Infection constitutes a serious adverse event in patients submitted to deep brain stimulation, often leading to removal of the device. We set to evaluate the potential role of immunoscintigraphy with  99m Tc-labelled antigranulocyte antibody fragments ( 99m Tc-sulesomab) in the management of infection following DBS.  99m Tc-sulesomab immunoscintigraphy seems to correlate well with the presence and extent of infection, thus contributing to differentiate between patients who should remove the hardware entirely at presentation and those who could undergo a more conservative approach. Also,  99m Tc-sulesomab immunoscintigraphy has a role in determining the most appropriate timing for reimplantation. Finally, we propose an algorithm for the management of infection following DBS surgery, based on the results of the  99m Tc-sulesomab immunoscintigraphy.

neurology research international

Role of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mmultiscripts><mml:mtext>T</mml:mtext></mml:mmultiscripts><mml:mtext>c</mml:mtext></mml:mrow></mml:math>-Sulesomab Immunoscintigraphy in the Management of Infection following Deep Brain Stimulation Surgery

Role ofTc-Sulesomab Immunoscintigraphy in the Management of Infection following Deep Brain Stimulation Surgery