Water-Soluble Chitosan Nanoparticles Inhibit Hypercholesterolemia Induced by Feeding a High-Fat Diet in Male Sprague-Dawley Rats | Zendy

Tao Yi | Zendy; Hongliang Zhang | Zendy; Bingbing Gao | Zendy; Jiao Guo | Zendy; Yinming Hu | Zendy; Zhengquan Su | Zendy

Open Access

Water-Soluble Chitosan Nanoparticles Inhibit Hypercholesterolemia Induced by Feeding a High-Fat Diet in Male Sprague-Dawley Rats

Author(s) -

Tao Yi,

Hongliang Zhang,

Bingbing Gao,

Jiao Guo,

Yinming Hu,

Zhengquan Su

Publication year - 2010

Publication title -

journal of nanomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.463

H-Index - 66

eISSN - 1687-4129

pISSN - 1687-4110

DOI - 10.1155/2011/814606

Subject(s) - chitosan , chitin , nanoparticle , superoxide dismutase , absorption (acoustics) , cholesterol , materials science , nuclear chemistry , food science , chemistry , biochemistry , antioxidant , nanotechnology , composite material

Chitosan, a deacetylated product of chitin, has been demonstrated to lower cholesterol in humans and animals. However, chitosan is not fully soluble in water which would influence absorption in the human intestine. In addition, water-soluble chitosan (WSC) has higher reactivity compared to chitosan. The present study was designed to clarify the effects of WSC and water-soluble chitosan nanoparticles (WSC-NPs) on hypercholesterolemia induced by feeding a high-fat diet in male Sprague-Dawley rats. WSC-NPs were prepared by the ionic gelation method and the spray-drying technique. The nanoparticles were spherical in shape and had a smooth surface. The mean size of WSC-NPs was 650 nm variing from 500 to 800 nm. Results showed that WSC-NPs reduced the blood lipids and plasma viscosity significantly and increased the serum superoxide dismutase (SOD) activities significantly. This paper is the first report of the lipid-lowering effects of WSC-NPs suggesting that the WSC-NPs could be used for the treatment of hypercholesterolemia

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