MoMuLV-ts-1: A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk | Zendy

Joy Chakraborty | Zendy; Henry Okonta | Zendy; Hussein Saeed Bagalb | Zendy; Joan Duggan | Zendy

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MoMuLV-ts-1: A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk

Author(s) -

Joy Chakraborty,

Henry Okonta,

Hussein Saeed Bagalb,

Joan Duggan

Publication year - 2011

Publication title -

advances in virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.956

H-Index - 25

eISSN - 1687-8647

pISSN - 1687-8639

DOI - 10.1155/2011/813651

Subject(s) - retrovirus , lymphoma , virology , biology , cancer research , gene , murine leukemia virus , offspring , mutant , virus , immunology , genetics , pregnancy

Our laboratory has developed a murine model of lymphoma via breast milk transmission of MoMuLV-ts-1 (Moloney murine leukemia virus-temperature sensitive mutant-1). Uninfected offspring suckled from infected surrogate mothers become infected and develop lymphoma. Multiple gene integration sites of ts-1 into the infected mouse genome including tacc3, aurka, ndel1, tpx2, p53, and rhamm were identified, and mRNA expressions were quantitated. These genes produce centrosomal proteins, which may be involved in abnormal chromosomal segregation leading to aneuploidy or multiploidy, thus causing lymphoma. Since there is no report to date on this retroviral model leading to centrosomal abnormality, and causing lymphoma development, this is a valuable and unique model to study the centrosomal involvement in lymphomagenesis.

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