A Validated RP-HPLC Method for the Determination of Atazanavir in Pharmaceutical Dosage Form | Zendy

S. Kondra | Zendy; J. V. L. N. Seshagiri Rao | Zendy; N. Appala Raju | Zendy; K. Mukkanti | Zendy

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A Validated RP-HPLC Method for the Determination of Atazanavir in Pharmaceutical Dosage Form

Author(s) -

S. Kondra,

J. V. L. N. Seshagiri Rao,

N. Appala Raju,

K. Mukkanti

Publication year - 2010

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2011/812879

Subject(s) - atazanavir , chemistry , chromatography , dosage form , acetonitrile , high performance liquid chromatography , capsule , medicine , botany , biology , family medicine , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy

A validated RP HPLC method for the estimation of atazanavir in capsule dosage form on YMC ODS 150 × 4.6 mm, 5 μ column using mobile phase composition of ammonium dihydrogen phosphate buffer (pH 2.5) with acetonitrile (55:45 v/v). Flow rate was maintained at 1.5 mL/min with 288 nm UV detection. The retention time obtained for atazanavir was at 4.7 min. The detector response was linear in the concentration range of 30 - 600 μg/mL. This method has been validated and shown to be specific, sensitive, precise, linear, accurate, rugged, robust and fast. Hence, this method can be applied for routine quality control of atazanavir in capsule dosage forms as well as in bulk drug.

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