PU.1 and Haematopoietic Cell Fate: Dosage Matters | Zendy

Ka Sin Mak | Zendy; Alister P. W. Funnell | Zendy; Richard C. M. Pearson | Zendy; Merlin Crossley | Zendy

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PU.1 and Haematopoietic Cell Fate: Dosage Matters

Author(s) -

Ka Sin Mak,

Alister P. W. Funnell,

Richard C. M. Pearson,

Merlin Crossley

Publication year - 2011

Publication title -

international journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.587

H-Index - 53

eISSN - 1687-8884

pISSN - 1687-8876

DOI - 10.1155/2011/808524

Subject(s) - haematopoiesis , regulator , transcription factor , lineage (genetic) , cell lineage , biology , master regulator , microbiology and biotechnology , transgene , mutant , computational biology , cellular differentiation , stem cell , genetics , gene

The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will discuss how a range of experiments in cell lines and mutant and transgenic mouse models have enhanced our knowledge of the mechanisms by which PU.1 drives lineage-specific differentiation during haematopoiesis.

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