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New platinum(II) complexes [PtCl( O,O′ -acac)(L)] ( 1 ) and [Pt( O,O′ -acac)( γ -acac)(L)] ( 2 ) (L = DMSO,  a ; DMS,  b ) containing a single chelated ( O,O′ -acac) ( 1 ), or one chelated and one  σ -bonded ( γ -acac) acetylacetonate ( 2 ) have been synthesized. The new Pt(II) complexes exhibited high  in vitro  cytotoxicity on  cisplatin  sensitive and resistant cell lines and showed negligible reactivity with nucleobases (Guo and 5′-GMP) but selective substitution of DMSO/DMS with soft biological nucleophiles, such as L-methionine. In order to assess the ability of the new complexes with respect to cisplatin to induce apoptosis by interaction with nongenomic targets, the Ames' test, a standard reverse mutation assay, was carried out on two  Salmonella typhimurium  strains (TA98 and TA100). Interestingly, the new complexes did not show the well-known mutagenic activity exhibited by cisplatin and are, therefore, able to activate apoptotic pathways without interacting with DNA.

Mutagenic Tests Confirm That New Acetylacetonate Pt(II) Complexes Induce Apoptosis in Cancer Cells Interacting with Nongenomic Biological Targets