Open AccessMelamine Nitrate: A Novel and Efficient Reagent for Regioselective Nitration of Phenols
Author(s) -
Yongqiang Chen,
Hong Jiang
Publication year - 2011
Publication title -
organic chemistry international
Language(s) - English
Resource type - Journals
eISSN - 2090-2018
pISSN - 2090-200X
DOI - 10.1155/2011/753142
Subject(s) - nitration , regioselectivity , reagent , melamine , chemistry , phenols , nitrate , organic chemistry , catalysis , filtration (mathematics) , combinatorial chemistry , statistics , mathematics
Melamine nitrate (MN) as a novel nitration reagent was easily prepared. Regioselective nitration of phenols to their corresponding o-nitrophenols occurred using MN with p-toluenesulfonic acid as catalyst in good to excellent yields. A distinct advantage of this method is the easy separation of products by simple filtration.
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