Quercetin and Bornyl Acetate Regulate T‐Lymphocyte Subsets and INF‐γ/IL‐4 Ratio In Utero in Pregnant Mice | Zendy

Xiaodan Wang | Zendy; Aituan Ma | Zendy; Wanyu Shi | Zendy; Meiying Geng | Zendy; Xiuhui Zhong | Zendy; Yantao Zhao | Zendy

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Quercetin and Bornyl Acetate Regulate T‐Lymphocyte Subsets and INF‐γ/IL‐4 Ratio In Utero in Pregnant Mice

Author(s) -

Xiaodan Wang,

Aituan Ma,

Wanyu Shi,

Meiying Geng,

Xiuhui Zhong,

Yantao Zhao

Publication year - 2010

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2011/745262

Subject(s) - in utero , quercetin , lymphocyte subsets , lymphocyte , chemistry , immunology , biology , pregnancy , fetus , biochemistry , t cell , immune system , genetics , antioxidant

The objective of this study is to investigate the antiabortive effects of Quercetin and Bornvl Acetate and their immunological modulation at maternal-fetal interface. Lipopolysaccharide (LPS) was injected via tail vein to induce abortion in mice which received Quercetin and Bornvl Acetate at days 4–7 of gestation. Uterine CD4+/CD8+ T lymphocytes and IFN- γ /IL-4 of each group ( n = 10) were detected by immunohistochemistry and enzyme-linked immunosorbent assay, respectively. The ratio of CD4+/CD8+ increased significantly ( P < .01) in the uterus of LPS-induced abortion mice. In the Quercetin and Bornvl Acetate pretreated mice followed by LPS administration, the ratio of CD4+/CD8+ dropped to 0.562 ± 0.021, lower than that of LPS-abortion group ( P < .01). The mean value of IFN- γ /IL-4 in LPS-treated mice was 0.310 ± 0.066, higher than that of Quercetin and Bornyl Acetate group. The results indicate that Quercetin and Bornyl Acetate have an antiabortive effect through modulation of immunological balance at maternal-fetal interface.

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