A New Candidate Supporting Drug, Rikkunshito, for the QOL in Advanced Esophageal Cancer Patients with Chemotherapy Using Docetaxel/5-FU/CDDP | Zendy

Junichi Seike | Zendy; Toru Sawada | Zendy; Naoya Kawakita | Zendy; Yota Yamamoto | Zendy; Yasuhiro Yuasa | Zendy; Hiromichi Yamai | Zendy; Hirokazu Takachi | Zendy; Takahiro Yoshida | Zendy; Akira Tangoku | Zendy

Open Access

A New Candidate Supporting Drug, Rikkunshito, for the QOL in Advanced Esophageal Cancer Patients with Chemotherapy Using Docetaxel/5-FU/CDDP

Author(s) -

Junichi Seike,

Toru Sawada,

Naoya Kawakita,

Yota Yamamoto,

Yasuhiro Yuasa,

Hiromichi Yamai,

Hirokazu Takachi,

Takahiro Yoshida,

Akira Tangoku

Publication year - 2011

Publication title -

international journal of surgical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 22

eISSN - 2090-1410

pISSN - 2090-1402

DOI - 10.1155/2011/715623

Subject(s) - nausea , docetaxel , medicine , vomiting , chemotherapy , adverse effect , anesthesia , oncology

Purpose . Docetaxel/5-FU/CDDP (DFP) therapy is a useful treatment for advanced esophageal cancer. However, adverse reactions such as chemotherapy-induced nausea and vomiting (CINV) interfere often with continuation of the chemotherapy. We investigated the efficacy of rikkunshito (TJ-43) on CINV. Methods . Nineteen patients who were going to undergo DFP therapy were enrolled. They were assigned to the following two groups: a TJ-43-treated group and -nontreated group. The following parameters were compared between the 2 groups: (1) the frequency of symptoms occurred, (2) vomiting, nausea, and anorexia score, and (3) QOL score. Results . The incidence of symptoms was lower in the TJ-43-treated group than that in the control group. The nausea score of the TJ-43-treated group was significantly lower than that of the control group. In the QOL score, the mood score and the ADL score decreased significantly in the control group. Conclusion . We recommend TJ-43 administration in patients undergoing DFP chemotherapy.

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