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The  in vitro  activity of six cathelicidin peptides against the reference strain Z of  Simkania negevensis  was investigated. Five peptides—PG-1, Bac7, SMAP-29, BMAP-27, and BMAP-28—proved to be active at very low concentrations (1 to 0.1  μ g/mL), while LL-37 cathelicidin was ineffective even at a concentration of 100  μ g/mL. In comparison to chlamydiae,  S. negevensis  proved to be more susceptible to the antimicrobial peptides tested.

Activity of Cathelicidin Peptides against Simkania negevensis