Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand | Zendy

Olivier Galy | Zendy; Isabelle Chemin | Zendy; Emilie Le Roux | Zendy; Stéphanie Villar | Zendy; Florence Le CalvezKelm | Zendy; Myriam Lereau | Zendy; Doriane Gouas | Zendy; Beatriz Vieco | Zendy; Iris Suárez | Zendy; María Cristivas | Zendy; Michèle Chevallier | Zendy; Heléne Norder | Zendy; Petcharin Srivatanakul | Zendy; Anant Karalak | Zendy; Suleeporn Sangrajrang | Zendy; Christian Trépo | Zendy; Pierre Hainaut | Zendy

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Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

Author(s) -

Olivier Galy,

Isabelle Chemin,

Emilie Le Roux,

Stéphanie Villar,

Florence Le CalvezKelm,

Myriam Lereau,

Doriane Gouas,

Beatriz Vieco,

Iris Suárez,

María Cristivas,

Michèle Chevallier,

Heléne Norder,

Petcharin Srivatanakul,

Anant Karalak,

Suleeporn Sangrajrang,

Christian Trépo,

Pierre Hainaut

Publication year - 2011

Publication title -

hepatitis research and treatment

Language(s) - English

Resource type - Journals

eISSN - 2090-1372

pISSN - 2090-1364

DOI - 10.1155/2011/697162

Subject(s) - hepatocellular carcinoma , medicine , occult , mutation , hepatitis b , virology , genotype , chronic hepatitis , cancer research , biology , gene , genetics , pathology , virus , alternative medicine

Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection and TP53 mutation and the other characterized by HCV infection and CTNNB1 mutation. We have investigated HBV/HCV infections and TP53 / CTNNB1 mutations in 26 HCC patients from Thailand. HBV DNA (genotype B or C) was detected in 19 (73%) of the cases, including 5 occult infections and 3 coinfections with HCV. TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S , suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development.

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