Ventilation/Perfusion SPECT for Diagnosis of Pulmonary Embolism and Other Diseases

V/P SPECT has the potential to become a first hand tool for diagnosis of pulmonary embolism based on standardized technology and new holistic interpretation criteria. Pretest probability helps clinicians choose the most appropriate objective test for diagnosis or exclusion of PE. Interpretation should also take into account all ventilation and perfusion patterns allowing diagnosis of other cardiopulmonary diseases than PE. In such contexts, V/P SPECT has excellent sensitivity and specificity. Nondiagnostic reports are ≤3%. V/P SPECT has no contraindication; it is noninvasive and has very low radiation exposure. Moreover, acquisition time for V/P SPECT is only 20 minutes. It allows quantification of PE extension which has an impact on individual treatment. It is uniquely useful for followup and research.