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Little is known on long-term outcomes in kidney transplantation. This study evaluated changes and predictors of generic and transplantation-specific health-related quality of life (HQoL) over six years in  N  = 102 kidney transplant survivors using the Short-form Health Survey-36 and the Transplant Effects questionnaire. Mixed models analysis was used to determine long-term outcomes. Emotional HQoL improved over time: Mental Component score, Mental Health, Energy ( P s = .000). Physical HQoL deteriorated: Physical Component Score ( P  = .001), Pain ( P  = .002). LRD transplant recipients had greater decline in physical functioning ( P  = .003) and PCS ( P  = .000) compared to cadaver recipients. Worry about the transplant ( P  = .036) and feelings of responsibility ( P  = .008) increased significantly over time. Worry about the transplant and perceived ability to work predicted 12.7% and 31.1% in variance in MCS and PCS, respectively. Efforts should be made to maintain HQoL and emotional outcomes with ongoing monitoring and support programs throughout the course of posttransplant care.

Prospective Changes in Health-Related Quality of Life and Emotional Outcomes in Kidney Transplantation over 6 Years