In Vitro and In Vivo Activities of Essential Oil from the Seed of Anethum graveolens L. against Candida spp. | Zendy

Hong Zeng | Zendy; Jun Tian | Zendy; Yuechen Zheng | Zendy; Xiaoquan Ban | Zendy; Jingsi Zeng | Zendy; Yehong Mao | Zendy; Youwei Wang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

In Vitro and In Vivo Activities of Essential Oil from the Seed of Anethum graveolens L. against Candida spp.

Author(s) -

Hong Zeng,

Jun Tian,

Yuechen Zheng,

Xiaoquan Ban,

Jingsi Zeng,

Yehong Mao,

Youwei Wang

Publication year - 2011

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2011/659704

Subject(s) - anethum graveolens , essential oil , fluconazole , candida krusei , candida albicans , in vivo , microbiology and biotechnology , candida parapsilosis , in vitro , candida tropicalis , minimum inhibitory concentration , biology , pharmacology , traditional medicine , chemistry , antifungal , medicine , antimicrobial , food science , biochemistry

The essential oil produced from the seed of Anethum graveolens L. (Umbelliferae) was tested in vitro and in vivo anti- Candida activity. The microbroth dilution method was used in the minimal inhibitory concentration (MIC), according to M27-A3 of the guidelines of the Clinical and Laboratory Standard Institute (CLSI). And then, efficacy evaluation of essential oil in the prophylaxis and treatment of experimental vaginal candidiasis was performed in immunosuppressed mice. The anti- Candida activity was analyzed by microbiological and histological techniques and was compared with that of fluconazole (FCZ). The results showed essential oil was active in vitro against all tested strains, with MICs ranging from 0.312 μ L/mL (for C. tropicalis, C. parapsilosis, and C. krusei ) to 0.625 μ L/mL (for 6 isolated C. albicans strains). Essential oil (2% v/v) was highly efficacious in accelerating C. albicans 09-1555 clearance from experimentally infected mice vagina by prophylaxis and therapeutic treatments. In both therapeutic efficacy and prophylaxis studies, the histological findings confirmed the microbiological results. The experimental results revealed that the tested essential oil is effective against vulvovaginal candidiasis in immunosuppressed mice.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research