Open AccessBiological and Spectral Studies of Newly Synthesized Triazole Schiff Bases and Their Si(IV), Sn(IV) Complexes
Author(s) -
Kiran Singh,
Parvesh Puri,
Yogender Kumar,
Chetan Sharma,
K. R. Aneja
Publication year - 2011
Publication title -
bioinorganic chemistry and applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.865
H-Index - 35
eISSN - 1565-3633
pISSN - 1687-479X
DOI - 10.1155/2011/654250
Subject(s) - chemistry , organosilicon , molar ratio , trigonal bipyramidal molecular geometry , octahedron , metal , schiff base , isopropyl , triazole , conductance , octahedral molecular geometry , 1,2,4 triazole , medicinal chemistry , stereochemistry , polymer chemistry , crystallography , molecule , organic chemistry , catalysis , crystal structure , mathematics , combinatorics
The Schiff bases HL 1-3 have been prepared by the reaction of 5-bromothiophene-2-carboxaldehyde with 4-amino-5-mercapto-3-methyl/propyl/isopropyl-s-triazole, respectively. Organosilicon(IV) and organotin(IV) complexes of formulae (CH 3 ) 2 MCl(L 1-3 ), (CH 3 ) 2 M(L 1-3 ) 2 were synthesized from the reaction of (CH 3 ) 2 MCl 2 and the Schiff bases in 1 : 1 and 1 : 2 molar ratio, where M = Si and Sn. The synthesized Schiff bases and their metal complexes have been characterized with the aid of various physicochemical techniques like elemental analyses, molar conductance, UV, IR, 1 H, 13 C, 29 Si, and 119 Sn NMR spectroscopy. Based on these studies, the trigonal bipyramidal and octahedral geometries have been proposed for these complexes. The ligands and their metal complexes have been screened in vitro against some bacteria and fungi.
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