Preparation of DNA/Gold Nanoparticle Encapsulated in Calcium Phosphate | Zendy

Tomoko Ito | Zendy; Koyuki Ibe | Zendy; Tomohiro Uchino | Zendy; Hiroyuki Ohshima | Zendy; Makoto Otsuka | Zendy

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Preparation of DNA/Gold Nanoparticle Encapsulated in Calcium Phosphate

Author(s) -

Tomoko Ito,

Koyuki Ibe,

Tomohiro Uchino,

Hiroyuki Ohshima,

Makoto Otsuka

Publication year - 2011

Publication title -

journal of drug delivery

Language(s) - English

Resource type - Journals

eISSN - 2090-3014

pISSN - 2090-3022

DOI - 10.1155/2011/647631

Subject(s) - dna , colloidal gold , calcium , phosphate , nanoparticle , hyaluronic acid , capsule , chemistry , coating , chemical engineering , nuclear chemistry , nanotechnology , materials science , biochemistry , organic chemistry , biology , anatomy , botany , engineering

Biocompatible DNA/gold nanoparticle complex with a protective calcium phosphate (CaP) coating was prepared by incubating DNA/gold nanoparticle complex coated by hyaluronic acid in SBF (simulated body fluid) with a Ca concentration above 2 mM. The CaP-coated DNA complex was revealed to have high compatibility with cells and resistance against enzymatic degradation. By immersion in acetate buffer (pH 4.5), the CaP capsule released the contained DNA complex. This CaP capsule including a DNA complex is promising as a sustained-release system of DNA complexes for gene therapy.

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